Corpus ID: 32560092

Effects of flufenamic acid, dexamethasone, and SP 54 (a pentosanpolysulphate) on the histological appearance of murine embryonic tibia explants cultured in vitro.

@article{Weischer1978EffectsOF,
  title={Effects of flufenamic acid, dexamethasone, and SP 54 (a pentosanpolysulphate) on the histological appearance of murine embryonic tibia explants cultured in vitro.},
  author={C. H. Weischer and K. Frey},
  journal={International journal of clinical pharmacology and biopharmacy},
  year={1978},
  volume={16 2},
  pages={
          72-7
        }
}
  • C. H. Weischer, K. Frey
  • Published 1978
  • Medicine
  • International journal of clinical pharmacology and biopharmacy
The histological investigation of cultured, embryonic tibia explants of NMRI-mice showed, after a six day period, that incubation concentrations of Flufenamic acid, SP54 (a Pentosanopolysulphate), and Dexamethasone (9alpha-Fluor-16-beta-Methyl-Prednisolone) predominantly induced resorptive and degenerative processes, in different degrees, affecting cartilage and bone matrix. In the experiments with Flufenamic acid and Dexamethasone, the degenerative processes were found to be accompanied by the… Expand