Effects of fluconazole on the secretome, the wall proteome, and wall integrity of the clinical fungus Candida albicans.

@article{Sorgo2011EffectsOF,
  title={Effects of fluconazole on the secretome, the wall proteome, and wall integrity of the clinical fungus Candida albicans.},
  author={Alice G. Sorgo and Clemens J. Heilmann and Henk L. Dekker and Martijn Bekker and Stanley Brul and Chris G. de Koster and Leo J. de Koning and Frans Klis},
  journal={Eukaryotic cell},
  year={2011},
  volume={10 8},
  pages={1071-81}
}
Fluconazole is a commonly used antifungal drug that inhibits Erg11, a protein responsible for 14α-demethylation during ergosterol synthesis. Consequently, ergosterol is depleted from cellular membranes and replaced by toxic 14α-methylated sterols, which causes increased membrane fluidity and drug permeability. Surface-grown and planktonic cultures of Candida albicans responded similarly to fluconazole at 0.5 mg/liter, showing reduced biomass formation, severely reduced ergosterol levels, and… CONTINUE READING

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