Effects of flt-3 ligand in combination with TPO on the expansion of megakaryocytic progenitors.

@article{Li2000EffectsOF,
  title={Effects of flt-3 ligand in combination with TPO on the expansion of megakaryocytic progenitors.},
  author={Kwan Wai Li and Min Yang and Audrey Carmen Lam and Fung Wan Yau and Patrick Yuen},
  journal={Cell transplantation},
  year={2000},
  volume={9 1},
  pages={
          125-31
        }
}
As an early acting growth factor, flt-3 ligand (FL) promotes the ex vivo expansion of hematopoietic stem and progenitor cells. The effect and mechanism of FL on the development of the megakaryocytic lineage remain unclear. In this study, we compared the effects of FL and stem cell factor (SCF) in combination with other megakaryocyte-promoting cytokines on the differentiation and proliferation of megakaryocytic progenitors and investigated the expression of flt-3 receptors on megakaryocytic cell… CONTINUE READING