Effects of flecainide on ventricular function: clinical and experimental correlations.

@article{Josephson1984EffectsOF,
  title={Effects of flecainide on ventricular function: clinical and experimental correlations.},
  author={Michelle A. Josephson and Norishige Ikeda and Bhim Pratap Singh},
  journal={The American journal of cardiology},
  year={1984},
  volume={53 5},
  pages={
          95B-100B
        }
}
Flecainide has unusual electrophysiologic properties and a high potency for the suppression of ventricular tachyarrhythmias. Little is known about its inotropic and hemodynamic actions. In isolated rabbit papillary muscle, it produced a concentration-dependent depression of contractile force, the threshold concentration being 1.0 micrograms/ml. In patients undergoing coronary angiography for ischemic heart disease and given 1 (n = 11) and 2 mg/kg (n = 11) of flecainide acetate i.v., there was… CONTINUE READING
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