Effects of fibrillin-1 degradation on microfibril ultrastructure.

@article{Kuo2006EffectsOF,
  title={Effects of fibrillin-1 degradation on microfibril ultrastructure.},
  author={Chiu-Liang Kuo and Zenzo Isogai and Douglas R. Keene and Noriko Hazeki and Robert N. Ono and Gerhard Sengle and Hans Peter Baechinger and Lynn Yasuko Sakai},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={282 6},
  pages={
          4007-20
        }
}
Current models of the elastic properties and structural organization of fibrillin-containing microfibrils are based primarily on microscopic analyses of microfibrils liberated from connective tissues after digestion with crude collagenase. Results presented here demonstrate that this digestion resulted in the cleavage of fibrillin-1 and loss of specific immunoreactive epitopes. The proline-rich region and regions near the second 8-cysteine domain in fibrillin-1 were easily cleaved by crude… CONTINUE READING
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