Effects of fetuin-A with diverse functions and multiple mechanisms on human health.

@article{ArifIcer2020EffectsOF,
  title={Effects of fetuin-A with diverse functions and multiple mechanisms on human health.},
  author={Mehmet Arif Icer and Hilal Yıldıran},
  journal={Clinical biochemistry},
  year={2020}
}

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References

SHOWING 1-10 OF 147 REFERENCES

Pathophysiological Implication of Fetuin-A Glycoprotein in the Development of Metabolic Disorders: A Concise Review

The protein has been shown to highly exacerbate insulin resistance (IR) through blocking insulin-stimulated glucose transporter 4 (GLUT-4) translocation and protein kinase B (Akt) activation, and appeared to interfere with downstream phosphorylation events in insulin receptor and insulin receptor substrate signaling.

Fetuin-A – Alpha2-Heremans-Schmid Glycoprotein: From Structure to a Novel Marker of Chronic Diseases Part 2. Fetuin-A – A Marker of Insulin Resistance and Related Chronic Diseases

Summary Fetuin-A is a secretory liver glycoprotein with multiple physiological functions such as regulation of insulin resistance, tissue calcification, bone metabolism, cellular proteolytic

Impact of Fetuin-A (AHSG) on Tumor Progression and Type 2 Diabetes

Fetuin-A that is synthesized, modified, and secreted by tumor cells may be more relevant in understanding the pathophysiological role of this enigmatic protein in tumors, as opposed to the relatively high serum concentrations of the liver derived protein.

Effects of nutritional status on serum fetuin-A level

It is indicated that high blood glucose levels increase hepatic fetuin-A release by activating extracellular signal-regulated kinase 1/2 enzymes and increased plasma free acids do the same effect by increasing NF-KB activity.

Fetuin-A: a novel link between obesity and related complications

Evidence suggests that elevated FetA level causes impaired glycemic control, as FetA has been implicated in impairment of insulin receptor signaling, toll-like receptor 4 activation, macrophage migration and polarization, adipocyte dysfunction, hepatocyte triacylglycerol accumulation and liver inflammation and fibrosis.

Multifunctional roles for serum protein fetuin-a in inhibition of human vascular smooth muscle cell calcification.

Evidence is provided that the uptake of the serum protein fetuin-A by VSMC is a key event in the inhibition of vesicle-mediated VSMC calcification, a condition associated with an elevated circulating calcium x phosphate product in patients with ESRD.

Fetuin-A (AHSG) and its usefulness in clinical practice. Review of the literature.

Fetuin-A has a diagnostic potential as a biomarker for liver dysfunction, cardiovascular diseases and disorders associated with metabolic syndrome and may be a marker of liver function and predictor of mortality in patients with cirrhosis and hepatocellular cancer.

A Hepatic Protein, Fetuin-A, Occupies a Protective Role in Lethal Systemic Inflammation

Experimental data suggest that fetuin-A is protective against lethal systemic inflammation partly by inhibiting active HMGB1 release.

The serum protein alpha 2-Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification.

A critical role is demonstrated of the serum protein alpha2-Heremans-Schmid glycoprotein (Ahsg) as an inhibitor of unwanted mineralization and a novel therapeutic concept to prevent ectopic calcification accompanying various diseases is provided.
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