Effects of fentanyl on natural killer cell activity and on resistance to tumor metastasis in rats. Dose and timing study.

@article{Shavit2004EffectsOF,
  title={Effects of fentanyl on natural killer cell activity and on resistance to tumor metastasis in rats. Dose and timing study.},
  author={Yehuda Shavit and Shamgar Ben-Eliyahu and Alexander Zeidel and Benzion Beilin},
  journal={Neuroimmunomodulation},
  year={2004},
  volume={11 4},
  pages={255-60}
}
OBJECTIVES Opiates, which serve an integral role in anesthesia, suppress immune function, particularly natural killer cell cytotoxicity (NKCC). NK cells play an important role in tumor and metastasis surveillance. We reported that large-dose fentanyl anesthesia induced prolonged suppression of NKCC in patients undergoing abdominal surgery. The immune modulatory effects of opiates may depend on the interaction between dose and time of administration. The present study examined the effects of… CONTINUE READING
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