Effects of fentanyl, alfentanil, remifentanil and sufentanil on loss of consciousness and bispectral index during propofol induction of anaesthesia.

@article{Lysakowski2001EffectsOF,
  title={Effects of fentanyl, alfentanil, remifentanil and sufentanil on loss of consciousness and bispectral index during propofol induction of anaesthesia.},
  author={Christopher Lysakowski and Lionel Dumont and Michela Pellegrini and François Clergue and Ed{\"o}m{\'e}r Tassonyi},
  journal={British journal of anaesthesia},
  year={2001},
  volume={86 4},
  pages={523-7}
}
The bispectral index (BIS) and a sedation score were used to determine and compare the effect of propofol in the presence of fentanyl, alfentanil, remifentanil and sufentanil. Seventy-five non-premedicated patients were assigned randomly into five groups (15 in each) to receive fentanyl, alfentanil, remifentanil, sufentanil or placebo. Opioids were administered using a target-con-trolled infusion device, to obtain the following predicted effect-site concentrations: fentanyl, 1.5 ng ml(-1… CONTINUE READING