Effects of fenfluramine on hepatic intermediary metabolism.

  title={Effects of fenfluramine on hepatic intermediary metabolism.},
  author={M. Geelen},
  journal={Biochemical pharmacology},
  volume={32 22},
  • M. Geelen
  • Published 1983
  • Biology, Medicine
  • Biochemical pharmacology
  • Effects of fenfluramine on hepatic intermediary metabolism have been studied using the isolated hepatocyte system. Fenfluramine inhibits the formation of glucose from lactate plus pyruvate and from alanine as well as the production of ketone bodies from added oleate. The latter observation suggests that inhibition of gluconeogenesis may result from a decrease in the level of mitochondrial acetyl-CoA. Fatty acid synthesis by hepatocytes is slightly stimulated by fenfluramine, perhaps as a… CONTINUE READING
    14 Citations
    Effects of benfluorex on fatty acid and glucose metabolism in isolated rat hepatocytes: from metabolic fluxes to gene expression.
    • 17
    • Highly Influenced
    • PDF
    Dexfenfluramine modulates hepatic glycogen metabolism by a calcium-dependent pathway.
    • 5
    Pharmacological Treatments That Affect CNS Activity: Serotonin
    • 35
    Dexfenfluramine. Its place in weight control.
    • 22


    Effect of fenfluramine on the intestinal absorption of triglycerides.
    • 21
    Studies on the inhibition of hepatic lipogenesis by N-6,O-2'-dibutyryl adenosine 3',5'-monophosphate.
    • R. Harris
    • Biology, Medicine
    • Archives of biochemistry and biophysics
    • 1975
    • 137
    Effect of different fatty acids on glycerolipid synthesis in isolated rat hepatocytes.
    • 110
    • PDF