Effects of fencamfamine withdrawal in rats.

@article{Planeta1994EffectsOF,
  title={Effects of fencamfamine withdrawal in rats.},
  author={Cleopatra da Silva Planeta and Roberto Delucia and Moacyr Luiz Aizenstein},
  journal={General pharmacology},
  year={1994},
  volume={25 5},
  pages={
          931-4
        }
}
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Repeated administration intensifies the reinforcing effect of fencamfamine in rats.
Rewarding properties of methylphenidate: sensitization by prior exposure to the drug and effects of dopamine D1- and D2-receptor antagonists.
TLDR
Data indicate that the rewarding properties of methylphenidate are sensitized by prior exposure to the drug and that both D1- and D2-receptors, the latter possibly more specifically, appear to be involved in the development of this sensitization.

References

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On the mechanism which mediates the effects of long-term administration of fencamfamine in rats.
TLDR
The results suggest that changes in pre- or postsynaptic DA receptors may underlie the tolerance and sensitization to the effects of fencamfamine.
Effect of enantiomers of deprenyl (selegiline) and amphetamine on physical abuse liability and cortical electrical activity in rats
Discriminative stimulus properties and schedule effects of fencamfamine in rats
Comparative biochemical and behavioural effects of fencamfamine and dl-amphetamine in rats
TOLERANCE PATTERN OF THE ANOREXIGENIC ACTION OF AMPHETAMINES, FENFLURAMINE, PHENMETRAZINE AND DIETHYLPROPION IN RATS
TLDR
The results indicate that so‐called tolerance to the anorexigenic effect of drugs is apparent rather than real and that the duration of food access is a determining factor.
Intravenous self-administration of fencamfamine and cocaine by beagle dogs under fixed-ratio and progressive-ratio schedules of reinforcement.
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