Corpus ID: 37171594

Effects of fenamates and other nonsteroidal anti-inflammatory drugs on rat brain GABAA receptors expressed in Xenopus oocytes.

@article{Woodward1994EffectsOF,
  title={Effects of fenamates and other nonsteroidal anti-inflammatory drugs on rat brain GABAA receptors expressed in Xenopus oocytes.},
  author={R. Woodward and L. Polenzani and R. Miledi},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1994},
  volume={268 2},
  pages={
          806-17
        }
}
Xenopus oocytes injected with poly(A)+ RNA from rat cerebral cortex express functional gamma-aminobutyric acid (GABA)A receptors with electrical properties and pharmacology similar to those of receptors studied in situ. Fenamates, a class of nonsteroidal anti-inflammatory drugs (NSAIDs), had a dual effect on GABA-activated membrane current responses. Currents elicited by low concentrations of GABA were potentiated, whereas currents elicited by high concentrations of GABA were inhibited. The… Expand
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