Effects of fatty acids on superoxide radical generation in leukocytes.

  title={Effects of fatty acids on superoxide radical generation in leukocytes.},
  author={Katsuko Kakinuma and Shigeki Minakami},
  journal={Biochimica et biophysica acta},
  volume={538 1},
Acetylated ferricytochrome c was employed for the detection of superoxide radicals (O-2) generated both in intact cells and in subcellular fractions of leukocytes. Certain saturated fatty acids, myristate in particular, induced the production of O-2 in leukocytes, suggesting a correlation between the formation of O-2 and the hydrophobic interaction of fatty acids with the leukocyte plasma membrane. As compared with O-2 radical generation from phagocytizing leukocytes a greater stimulation of O… CONTINUE READING
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