Effects of fatty acids, fatty amines and propylene glycol on rat stratum corneum lipids and proteins in vitro measured by fourier transform infrared/attenuated total reflection (FT-IR/ATR) spectroscopy.

@article{Takeuchi1992EffectsOF,
  title={Effects of fatty acids, fatty amines and propylene glycol on rat stratum corneum lipids and proteins in vitro measured by fourier transform infrared/attenuated total reflection (FT-IR/ATR) spectroscopy.},
  author={Yoshikazu Takeuchi and Hidehito Yasukawa and Yumiko Yamaoka and Yoshio Kato and Yasuko Morimoto and Yoshinobu Fukumori and Tomoaki Fukuda},
  journal={Chemical \& pharmaceutical bulletin},
  year={1992},
  volume={40 7},
  pages={
          1887-92
        }
}
Fourier transform infrared/attenuated total reflection (FT-IR/ATR) spectroscopy was used to examine the effect of fatty acids, fatty amines and propylene glycol (PG) on the molecular mobility of rat stratum corneum lipids and keratinized proteins, using a hydrophobic solute, indomethacin, and a polar solute, 5- and 6-carboxyfluorescein (CF). Treatment of the skin with either oleic acid or oleylamine resulted in significant CH2 C-H asymmetric stretching band shifts and broadening. The extent of… 
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