Effects of fasting and re-feeding on the expression of Dec1, Per1, and other clock-related genes.

@article{Kawamoto2006EffectsOF,
  title={Effects of fasting and re-feeding on the expression of Dec1, Per1, and other clock-related genes.},
  author={Takeshi Kawamoto and Mitsuhide Noshiro and Masae Furukawa and Kiyomasa K Honda and Ayumu Nakashima and Taichi Ueshima and Emiko Usui and Yuki Katsura and Katsumi Fujimoto and Sato Honma and Ken-ichi Honma and Taizo Hamada and Yukio Kato},
  journal={Journal of biochemistry},
  year={2006},
  volume={140 3},
  pages={401-8}
}
To elucidate the food-entrainable oscillatory mechanism of peripheral clock systems, we examined the effect of fasting on circadian expression of clock genes including Dec1 and Dec2 in mice. Withholding of food for 2 days had these effects: the expression level of Dec1 mRNA decreased in all tissues examined, although Per1 mRNA level markedly increased; Per2 expression was reduced in the liver and heart only 42-46 h after the start of fasting; and expression profiles of Dec2 and Bmal1 were… CONTINUE READING

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