Effects of factor IX or factor XI deficiency on ferric chloride-induced carotid artery occlusion in mice.

@article{Wang2005EffectsOF,
  title={Effects of factor IX or factor XI deficiency on ferric chloride-induced carotid artery occlusion in mice.},
  author={Xinkang Wang and Qiufang Cheng and Lin Xu and Giora G Z Feuerstein and M-Y F Hsu and Patricia L. Smith and Dietmar A. Seiffert and William A. Schumacher and Martin L. Ogletree and David Gailani},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2005},
  volume={3 4},
  pages={695-702}
}
Factor XI (FXI) and factor IX (FIX) are zymogens of plasma serine proteases required for normal hemostasis. The purpose of this work was to evaluate FXI and FIX as potential therapeutic targets by means of a refined ferric chloride (FeCl(3))-induced arterial injury model in factor-deficient mice. Various concentrations of FeCl(3) were used to establish the arterial thrombosis model in C57BL/6 mice. Carotid artery blood flow was completely blocked within 10 min in C57BL/6 mice by application of… CONTINUE READING