Effects of ezetimibe added to statin therapy on markers of cholesterol absorption and synthesis and LDL-C lowering in hyperlipidemic patients.

@article{Thongtang2012EffectsOE,
  title={Effects of ezetimibe added to statin therapy on markers of cholesterol absorption and synthesis and LDL-C lowering in hyperlipidemic patients.},
  author={Nuntakorn Thongtang and Jianxin Lin and Ernst J. Schaefer and Robert S. Lowe and Joanne E. Tomassini and Arvind K. Shah and Andrew M. Tershakovec},
  journal={Atherosclerosis},
  year={2012},
  volume={225 2},
  pages={388-96}
}
OBJECTIVE Statins inhibit cholesterol synthesis but can upregulate cholesterol absorption, with higher doses producing larger effects. Ezetimibe inhibits cholesterol absorption but also upregulates synthesis. We tested whether ezetimibe added to on-going statin therapy would be most effective in lowering LDL-cholesterol (LDL-C) in subjects on high-potency statins and whether these effects would be related to alterations in cholesterol absorption (β-sitosterol) and synthesis (lathosterol… CONTINUE READING
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