Effects of extracellular sodium on cytosolic calcium, PGE2 and cAMP in papillary collecting tubule cells.


An increase in cytosolic calcium (Cai2+), induced by an increase in extracellular calcium concentration or addition of the calcium ionophore A23187, has been shown to suppress basal and AVP responsive cAMP and inhibit water flow in the collecting tubule. In the present study, the relationships between extracellular Na+ concentration, Cai2+, PGE2 and AVP… (More)

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