Effects of extracellular calcium and surgical techniques on restoration of axonal continuity by polyethylene glycol fusion following complete cut or crush severance of rat sciatic nerves.

@article{Ghergherehchi2016EffectsOE,
  title={Effects of extracellular calcium and surgical techniques on restoration of axonal continuity by polyethylene glycol fusion following complete cut or crush severance of rat sciatic nerves.},
  author={Cameron L Ghergherehchi and George D Bittner and Robert Louis Hastings and Michelle A Mikesh and David Colton Riley and Richard C Trevino and Timothy J Schallert and Wesley P Thayer and Solomon Raju Bhupanapadu Sunkesula and T N Ha and Nicolas Antonio Roa Munoz and Monika Pyarali and Aakarshita Bansal and Andrew D Poon and Alexander T Mazal and Tyler Andrew Smith and Nicole Shi-Bao. Wong and Patrick J Dunne},
  journal={Journal of neuroscience research},
  year={2016},
  volume={94 3},
  pages={
          231-45
        }
}
Complete crush or cut severance of sciatic nerve axons in rats and other mammals produces immediate loss of axonal continuity. Loss of locomotor functions subserved by those axons is restored only after months, if ever, by outgrowths regenerating at ∼1 mm/day from the proximal stumps of severed axonal segments. The distal stump of a severed axon typically begins to degenerate in 1-3 days. We recently developed a polyethylene glycol (PEG) fusion technology, consisting of sequential exposure of… CONTINUE READING
BETA
3
Twitter Mentions

References

Publications referenced by this paper.
SHOWING 1-10 OF 38 REFERENCES

Principals of neural science, 5th ed

ER Kandel, JH Schwartz, TM Jessell, SA Siegelbaum, AJ. Hudspeth
  • New York: Elsevier. p 1760.
  • 2014
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Blocking the P2X7 receptor improves outcomes after axonal fusion.

  • The Journal of surgical research
  • 2013
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Hydrophilic polymers

KW Sexton, AC Pollins, +5 authors WP. Thayer
  • 2012
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Similar Papers

Loading similar papers…