Effects of external calcium, calcium channel-blocking agents, and stimulation frequency on cycle length-dependent changes in canine cardiac action potential duration.

@article{Colatsky1980EffectsOE,
  title={Effects of external calcium, calcium channel-blocking agents, and stimulation frequency on cycle length-dependent changes in canine cardiac action potential duration.},
  author={Thomas J. Colatsky and Perry M. Hogan},
  journal={Circulation research},
  year={1980},
  volume={46 4},
  pages={543-52}
}
Action potentials were recorded from canine Purkinje fibers to evaluate the effects of external calcium and the slow inward current-blocking agents, manganese and verapamil, on the relationship between action potential duration and diastolic interval during both steady state and premature excitation. Elevated external calcium shortened the action potential without changing the dependence of either steady state or premature responses on the preceding diastolic interval. The effects of elevated… CONTINUE READING
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