Effects of external Rb+ on inward rectifier K+ channels of bovine pulmonary artery endothelial cells

@article{Silver1994EffectsOE,
  title={Effects of external Rb+ on inward rectifier K+ channels of bovine pulmonary artery endothelial cells},
  author={Marcia R Silver and Mark S. Shapiro and Thomas E DeCoursey},
  journal={The Journal of General Physiology},
  year={1994},
  volume={103},
  pages={519 - 548}
}
Inward rectifier (IR) K+ channels of bovine pulmonary artery endothelial cells were studied using the whole-cell, cell-attached, and outside-out patch-clamp configurations. The effects of Rb+ on the voltage dependence and kinetics of IR gating were explored, with [Rb+]o + [K+]o = 160 mM. Partial substitution of Rb+ for K+ resulted in voltage-dependent reduction of inward currents, consistent with Rb+ being a weakly permeant blocker of the IR. In cells studied with a K(+)-free pipette solution… CONTINUE READING

References

Publications referenced by this paper.

Inactivation of the potassium conductance and related phenomena caused by quaternary ammonium ion injection in squid axons

  • C. M. Armstrong
  • Journal of General Physiology .

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