Effects of extended electrical kindling on exploratory behavior and spatial learning.

@article{Cammisuli1997EffectsOE,
  title={Effects of extended electrical kindling on exploratory behavior and spatial learning.},
  author={S Cammisuli and Michael P Murphy and Candace J Ikeda-Douglas and V Balkissoon and R M D Holsinger and Elizabeth Head and Michael Michael and Ronald J Racine and Norton William Milgram},
  journal={Behavioural brain research},
  year={1997},
  volume={89 1-2},
  pages={179-90}
}
Short-term electrical kindling, a widely used experimental model of epilepsy, appears to have little effect on behavior. The effects of extended kindling are largely unknown. Rats implanted with kindling electrodes in amygdala (AM) or perforant path (PP) received 300 kindling trials over approximately 7 months, and were tested in the Morris watermaze after a 7-10 day recovery period. Kindled animals were impaired during the initial training on hidden-platform acquisition, but not in retention… CONTINUE READING
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