Effects of extended-access self-administration and deprivation on breakpoints maintained by cocaine in rats

@article{Liu2004EffectsOE,
  title={Effects of extended-access self-administration and deprivation on breakpoints maintained by cocaine in rats},
  author={Yu hsiang Liu and David C. S. Roberts and Drake Morgan},
  journal={Psychopharmacology},
  year={2004},
  volume={179},
  pages={644-651}
}
Animal models that identify the effects of self-administration histories on subsequent patterns, levels of intake, and other aspects of reinforcement will help clarify the controlling variables of human drug use. Identify the effects of extended-access to cocaine and 1 or 7 days of deprivation on cocaine-maintained breakpoints on a progressive ratio (PR) schedule of reinforcement. Male, Sprague–Dawley rats were trained to self-administer intravenous cocaine (expt 1: 1.5 mg/kg per infusion; expt… CONTINUE READING

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