Effects of exposure to polychlorinated biphenyls and organochlorine pesticides on thyroid function during pregnancy.

@article{Chevrier2008EffectsOE,
  title={Effects of exposure to polychlorinated biphenyls and organochlorine pesticides on thyroid function during pregnancy.},
  author={Jonathan Chevrier and Brenda Eskenazi and Nina T. Holland and A S A Bradman and Dana Boyd Barr},
  journal={American journal of epidemiology},
  year={2008},
  volume={168 3},
  pages={
          298-310
        }
}
In this study, the authors' objective was to determine whether serum concentrations of polychlorinated biphenyls (PCBs), hexachlorobenzene, p,p'-dichlorodiphenyl trichloroethane (DDT), o,p'-DDT, and p,p'-dichlorodiphenyl dichloroethylene (DDE) are associated with thyroid function during pregnancy. These compounds, as well as thyroid-stimulating hormone, total thyroxine, and free thyroxine, were measured in serum samples collected between October 1999 and October 2000 from 334 pregnant women… Expand
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TLDR
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Serum dioxin concentrations and thyroid hormone levels in the Seveso Women's Health Study.
TLDR
TCDD exposure, particularly exposure before menarche, may have enduring impacts on women's total thyroxine levels, and initial exposure appears to be more influential than remaining body burden. Expand
Thyroid Hormone Levels of Pregnant Inuit Women and Their Infants Exposed to Environmental Contaminants
TLDR
There is little evidence that the environmental contaminants analyzed in this study affect thyroid hormone status in Inuit mothers and their infants within the first year of life. Expand
Environmental pollutants and the thyroid.
TLDR
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Long-term exposure to organochlorine pesticides and thyroid status in adults in a heavily contaminated area in Brazil.
TLDR
It is suggested that OC pesticides can affect the thyroid system through gender-specific mechanisms that may differ among compounds, and further detailed investigations and health monitoring should be warranted for this population. Expand
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Findings suggest possible threshold level in positive effect of PCBs on FT4 and TT3 level which seems to be individual and located somewhere around the PCBs level of 1000 ng/g, however, highly significant negative association of both FT4and TT3 with TSH was found in each of above indicated PCBs categories. Expand
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Out of the analyzed pesticides, the concentration of p,p'-DDT and its metabolites was higher in all the subjects, but dieldrin was found to be significantly high in the hypothyroid women, and the correlation analysis for d yieldrin and depleted T4 levels in hypothyroxine women elicited an inverse relationship between them. Expand
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