Effects of exposure to polychlorinated biphenyls and organochlorine pesticides on thyroid function during pregnancy.

@article{Chevrier2008EffectsOE,
  title={Effects of exposure to polychlorinated biphenyls and organochlorine pesticides on thyroid function during pregnancy.},
  author={Jonathan Chevrier and Brenda Eskenazi and Nina T. Holland and A S A Bradman and Dana Boyd Barr},
  journal={American journal of epidemiology},
  year={2008},
  volume={168 3},
  pages={
          298-310
        }
}
In this study, the authors' objective was to determine whether serum concentrations of polychlorinated biphenyls (PCBs), hexachlorobenzene, p,p'-dichlorodiphenyl trichloroethane (DDT), o,p'-DDT, and p,p'-dichlorodiphenyl dichloroethylene (DDE) are associated with thyroid function during pregnancy. These compounds, as well as thyroid-stimulating hormone, total thyroxine, and free thyroxine, were measured in serum samples collected between October 1999 and October 2000 from 334 pregnant women… 

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  • E. PearceL. Braverman
  • Biology, Medicine
    Best practice & research. Clinical endocrinology & metabolism
  • 2009
...

References

SHOWING 1-10 OF 83 REFERENCES

Thyroid Hormones in Pregnancy in Relation to Environmental Exposure to Organochlorine Compounds and Mercury

A significant negative correlation between maternal total triiodothyronine levels and three non-coplanar congeners, three pesticides, and inorganic Hg in healthy women recruited during pregnancy is found.

Effects of Dioxins and Polychlorinated Biphenyls on Thyroid Hormone Status of Pregnant Women and Their Infants

Elevated levels of dioxins and PCB can alter the human thyroid hormone status, and higher PCDD, PCDF, and PCB levels in human milk correlated significantly with lower plasma levels of maternal total triiodothyronine and total thyroxine and with higher Plasma levels of TSH in the infants in the 2nd wk and 3rd mo after birth.

Associations between Prenatal Exposure to Polychlorinated Biphenyls and Neonatal Thyroid-Stimulating Hormone Levels in a Mexican-American Population, Salinas Valley, California

The results support grouping PCB congeners based on their potential mechanism of action of enzyme induction when investigating associations with TH and suggest that PCBs affect TH homeostasis even at the low background level of exposure found in the CHAMA-COS population.

Factors predicting organochlorine pesticide levels in pregnant Latina women living in a United States agricultural area

Although the weight of evidence from this study indicates that most exposure occurred before moving to the United States, the results for HCB indicate the possibility of ongoing exposure in this country.

Comparison of polychlorinated biphenyl levels across studies of human neurodevelopment.

The results will facilitate a direct comparison of the findings on PCBs and neurodevelopment when they are published for all 10 studies, using a combination of data from original investigators, laboratory reanalyses, calculations based on published data, and expert opinion.

In utero exposure to background concentrations of DDT and cognitive functioning among preschoolers.

Prenatal exposure to background, low-level concentrations of DDT was associated with a decrease in preschoolers' cognitive skills, and these results should be considered when evaluating the risk and benefits of spraying DDT during antimalaria and other disease-vector campaigns.

Breastfeeding, exposure to organochlorine compounds, and neurodevelopment in infants.

Prenatal exposure to p,p'DDE was associated with a delay in mental and psychomotor development at 13 months and long-term breastfeeding was found to be beneficial to neurodevelopment, potentially counterbalancing the impact of exposure to these chemicals through breast milk.
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