Effects of exogenous stress protein 70 on the functional properties of human promonocytes through binding to cell surface and internalization.

@article{Guzhova1998EffectsOE,
  title={Effects of exogenous stress protein 70 on the functional properties of human promonocytes through binding to cell surface and internalization.},
  author={Irina V Guzhova and Andr{\'e}a C.V. Arnholdt and Zalfia A Darieva and Alexander V Kinev and Elena B Lasunskaia and Kenneth Nilsson and V. M. Bozhkov and Alexey P. Voronin and Boris A Margulis},
  journal={Cell stress & chaperones},
  year={1998},
  volume={3 1},
  pages={67-77}
}
The presence of antibodies against the major stress protein, Hsp70, in patients with autoimmune diseases led us to hypothesize that Hsp70 may occur extracellularly, and could exert chaperoning and regulatory effects on various cells. We examined the action of pure Hsp/Hsc70 on the main physiological functions of human promonocytic U-937 cells. The protein was isolated from calf muscle and was shown to be a mixture of inducible Hsp70 (60%) and constitutive Hsc70 (40%) isoforms. It was observed… CONTINUE READING

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