Effects of exogenous melatonin on sleep: a meta-analysis.

@article{Brzezinski2005EffectsOE,
  title={Effects of exogenous melatonin on sleep: a meta-analysis.},
  author={A. Brzezinski and M. Vangel and R. Wurtman and G. Norrie and I. Zhdanova and A. Ben-Shushan and I. Ford},
  journal={Sleep medicine reviews},
  year={2005},
  volume={9 1},
  pages={
          41-50
        }
}
Exogenous melatonin reportedly induces drowsiness and sleep, and may ameliorate sleep disturbances, including the nocturnal awakenings associated with old age. However, existing studies on the soporific efficacy of melatonin have been highly heterogeneous in regard to inclusion and exclusion criteria, measures to evaluate insomnia, doses of the medication, and routes of administration. We reviewed and analyzed (by meta-analysis) available information on effects of exogenous melatonin on sleep… Expand
Exogenous melatonin as a treatment for secondary sleep disorders: A systematic review and meta-analysis
TLDR
Pooled data demonstrate that exogenous melatonin lowers sleep onset latency and increases total sleep time, whereas it has little if any effect on sleep efficiency. Expand
Evidence for the efficacy of melatonin in the treatment of primary adult sleep disorders.
TLDR
The most convincing evidence for exogenous melatonin use was in reducing sleep onset latency in primary insomnia, delayed sleep phase syndrome, and regulating the sleep-wake patterns in blind patients compared with placebo, which highlights the potential importance of melatonin in treating certain first degree sleep disorders. Expand
Exogenous melatonin for sleep problems in individuals with intellectual disability: a meta‐analysis
TLDR
A meta‐analysis of placebo‐controlled randomized trials of melatonin in individuals with intellectual disabilities and sleep problems showed that melatonin treatment decreased sleep latency, increased total sleep time, and significantly decreased the number of wakes per night. Expand
Melatonin effects on macro sleep architecture in Alzheimer ’ s disease patients
The objective of this study was to determine the effects of 5mg. immediate release melatonin on the macro sleep architecture in eight patients diagnosed with middle to moderate Alzheimer’s diseaseExpand
The use and misuse of exogenous melatonin in the treatment of sleep disorders
  • R. Riha
  • Medicine
  • Current opinion in pulmonary medicine
  • 2018
TLDR
There is evidence for the efficacy of melatonin in the management of insomnia and some intrinsic disorders of circadian rhythm in adults and children as well as in reducing sleep onset latency in jet-lag and shift work disorder in adults. Expand
Melatonin and sleep in aging population
TLDR
Results indicate that exogenous melatonin is more effective to promote sleep in the presence of a diminished production of endogenous melatonin. Expand
Melatonin and Melatonergic Drugs on Sleep: Possible Mechanisms of Action
TLDR
Ramelteon is a novel MT1 and MT2 melatonergic agonist that has specific effects on melatonin receptors in the SCN and is effective in promoting sleep in experimental animals such as cats and monkeys, and in clinical trials, ramelteon reduced sleep onset latency and promoted sleep in patients with chronic insomnia, including an older adult population. Expand
[Melatonin in therapy of sleep disorders age-related estrogen deficiency].
TLDR
The use of melatonin drugs, including melaxen in a dose of 3 mg during 3 month, is one of the main methods of treatment of sleep disorders in age-related estrogen deficiency. Expand
The effect of prolonged-release melatonin on sleep measures and psychomotor performance in elderly patients with insomnia
Objectives of this study were to investigate the effects of prolonged-release melatonin 2 mg (PRM) on sleep and subsequent daytime psychomotor performance in patients aged ≥55 years with primaryExpand
Prolonged-release melatonin for the treatment of insomnia: targeting quality of sleep and morning alertness
TLDR
Prolonged-release (PR) melatonin (Circadin ®, Neurim Pharmaceuticals, Tel-Aviv, Israel) is a nonbenzodiazepine licensed to treat primary insomnia in patients aged 55 years and older and has been shown to be effective in improving quality of sleep and morning alertness. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 73 REFERENCES
Effect of Sustained Nocturnal Transbuccal Melatonin Administration on Sleep and Temperature in Elderly Insomniacs
TLDR
The results from the present study suggest that sustained nocturnal administration of melatonin, in the low pharmacological range, might be of limited clinical benefit in this subject population. Expand
Melatonin and insomnia
TLDR
The data indicate that melatonin is probably of no clinical value in the management of psychophysiological insomnia and that sleep had subjectively improved to a minor extent in the week of active treatment. Expand
Daytime melatonin administration in elderly good and poor sleepers: effects on core body temperature and sleep latency.
TLDR
It is suggested that although short-term exogenous oral daytime melatonin has significant hypothermic and hypnotic effects in aged women, the size of the effects is modest. Expand
Sleep‐inducing effects of low doses of melatonin ingested in the evening
TLDR
Exogenous melatonin may be useful in treating insomnia and nocturnal melatonin secretion may be involved in physiologic sleep onset, as assessed with mood and performance tests administered on the morning after treatment. Expand
Effects of a Low Dose of Melatonin on Sleep in Children with Angelman Syndrome
TLDR
The data suggest that a moderate increase in circulating melatonin levels significantly reduces motor activity during the sleep period in Angelman syndrome children, and promotes sleep. Expand
Melatonin acutely improves the neuroendocrine architecture of sleep in blind individuals.
TLDR
It is concluded that in totally blind individuals the single administration of a clearly pharmacological dose of melatonin can improve sleep function by synchronizing in time the inhibition of pituitary-adrenal activity with central nervous sleep processes. Expand
Melatonin in patients with reduced REM sleep duration: two randomized controlled trials.
TLDR
The findings show that exogenous melatonin, when administered at the appropriate time, seems to normalize circadian variation in human physiology and may have a strong impact on general health, especially in the elderly and in shift workers. Expand
Melatonin treatment for age-related insomnia.
Older people typically exhibit poor sleep efficiency and reduced nocturnal plasma melatonin levels. The daytime administration of oral melatonin to younger people, in doses that raise their plasmaExpand
Improvement of sleep quality in elderly people by controlled-release melatonin
TLDR
Controlled-release melatonin replacement therapy effectively improves sleep quality in this population of elderly people and may have an important role in the high frequency of insomnia among elderly people. Expand
Sleep-promoting and hypothermic effects of daytime melatonin administration in humans.
TLDR
It is suggested that melatonin may be an effective method of promoting sleep for individuals attempting to sleep during their subjective day, such as shiftworkers and individuals rapidly traveling across multiple time zones. Expand
...
1
2
3
4
5
...