Effects of exogenous melatonin on sleep: a meta-analysis.

  title={Effects of exogenous melatonin on sleep: a meta-analysis.},
  author={Amnon Brzezinski and Mark G. Vangel and Richard J. Wurtman and Gillian Norrie and Irina V. Zhdanova and Abraham Ben-Shushan and Ian Ford},
  journal={Sleep medicine reviews},
  volume={9 1},

Figures and Tables from this paper

Evidence for the efficacy of melatonin in the treatment of primary adult sleep disorders.

Exogenous melatonin for sleep problems in individuals with intellectual disability: a meta‐analysis

A meta‐analysis of placebo‐controlled randomized trials of melatonin in individuals with intellectual disabilities and sleep problems showed that melatonin treatment decreased sleep latency, increased total sleep time, and significantly decreased the number of wakes per night.

Melatonin effects on macro sleep architecture in Alzheimer ’ s disease patients

It was concluded that melatonin can improve sleep in patients with middle to moderate Alzheimer’s disease, especially during the second night of treatment.

Clinical Use of Melatonin in the Treatment of Sleep Disorders

  • A. ZakharovE. Khivintseva
  • Psychology, Biology
    Melatonin - The Hormone of Darkness and its Therapeutic Potential and Perspectives
  • 2020
The prospects of using melatonin due to its chronobiological effect in other sleep disorders, such as parasomnia, sleep-dependent respiratory disorders, and hypersomnia, are emphasized.

The use and misuse of exogenous melatonin in the treatment of sleep disorders

  • R. Riha
  • Medicine, Psychology
    Current opinion in pulmonary medicine
  • 2018
There is evidence for the efficacy of melatonin in the management of insomnia and some intrinsic disorders of circadian rhythm in adults and children as well as in reducing sleep onset latency in jet-lag and shift work disorder in adults.

Melatonin and Melatonergic Drugs on Sleep: Possible Mechanisms of Action

Ramelteon is a novel MT1 and MT2 melatonergic agonist that has specific effects on melatonin receptors in the SCN and is effective in promoting sleep in experimental animals such as cats and monkeys, and in clinical trials, ramelteon reduced sleep onset latency and promoted sleep in patients with chronic insomnia, including an older adult population.

[Melatonin in therapy of sleep disorders age-related estrogen deficiency].

The use of melatonin drugs, including melaxen in a dose of 3 mg during 3 month, is one of the main methods of treatment of sleep disorders in age-related estrogen deficiency.

The effect of prolonged-release melatonin on sleep measures and psychomotor performance in elderly patients with insomnia

Objectives of this study were to investigate the effects of prolonged-release melatonin 2 mg (PRM) on sleep and subsequent daytime psychomotor performance in patients aged ≥55 years with primary



Effect of Sustained Nocturnal Transbuccal Melatonin Administration on Sleep and Temperature in Elderly Insomniacs

The results from the present study suggest that sustained nocturnal administration of melatonin, in the low pharmacological range, might be of limited clinical benefit in this subject population.

Melatonin and insomnia

The data indicate that melatonin is probably of no clinical value in the management of psychophysiological insomnia and that sleep had subjectively improved to a minor extent in the week of active treatment.

Daytime melatonin administration in elderly good and poor sleepers: effects on core body temperature and sleep latency.

It is suggested that although short-term exogenous oral daytime melatonin has significant hypothermic and hypnotic effects in aged women, the size of the effects is modest.

Sleep‐inducing effects of low doses of melatonin ingested in the evening

Effects of a Low Dose of Melatonin on Sleep in Children with Angelman Syndrome

The data suggest that a moderate increase in circulating melatonin levels significantly reduces motor activity during the sleep period in Angelman syndrome children, and promotes sleep.

Melatonin acutely improves the neuroendocrine architecture of sleep in blind individuals.

It is concluded that in totally blind individuals the single administration of a clearly pharmacological dose of melatonin can improve sleep function by synchronizing in time the inhibition of pituitary-adrenal activity with central nervous sleep processes.

Melatonin in patients with reduced REM sleep duration: two randomized controlled trials.

The findings show that exogenous melatonin, when administered at the appropriate time, seems to normalize circadian variation in human physiology and may have a strong impact on general health, especially in the elderly and in shift workers.

Melatonin treatment for age-related insomnia.

Older people typically exhibit poor sleep efficiency and reduced nocturnal plasma melatonin levels. The daytime administration of oral melatonin to younger people, in doses that raise their plasma

Sleep-promoting and hypothermic effects of daytime melatonin administration in humans.

It is suggested that melatonin may be an effective method of promoting sleep for individuals attempting to sleep during their subjective day, such as shiftworkers and individuals rapidly traveling across multiple time zones.