Effects of exogenous melatonin on sleep: a meta-analysis.

@article{Brzezinski2005EffectsOE,
  title={Effects of exogenous melatonin on sleep: a meta-analysis.},
  author={Amnon Brzezinski and Mark G. Vangel and Richard J. Wurtman and Gillian Norrie and Irina V. Zhdanova and Abraham Ben-Shushan and Ian Ford},
  journal={Sleep medicine reviews},
  year={2005},
  volume={9 1},
  pages={
          41-50
        }
}
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References

SHOWING 1-10 OF 63 REFERENCES

Effect of Sustained Nocturnal Transbuccal Melatonin Administration on Sleep and Temperature in Elderly Insomniacs

The results from the present study suggest that sustained nocturnal administration of melatonin, in the low pharmacological range, might be of limited clinical benefit in this subject population.

Melatonin and insomnia

The data indicate that melatonin is probably of no clinical value in the management of psychophysiological insomnia and that sleep had subjectively improved to a minor extent in the week of active treatment.

Daytime melatonin administration in elderly good and poor sleepers: effects on core body temperature and sleep latency.

It is suggested that although short-term exogenous oral daytime melatonin has significant hypothermic and hypnotic effects in aged women, the size of the effects is modest.

Sleep‐inducing effects of low doses of melatonin ingested in the evening

Effects of a Low Dose of Melatonin on Sleep in Children with Angelman Syndrome

The data suggest that a moderate increase in circulating melatonin levels significantly reduces motor activity during the sleep period in Angelman syndrome children, and promotes sleep.

Melatonin acutely improves the neuroendocrine architecture of sleep in blind individuals.

It is concluded that in totally blind individuals the single administration of a clearly pharmacological dose of melatonin can improve sleep function by synchronizing in time the inhibition of pituitary-adrenal activity with central nervous sleep processes.

Melatonin in patients with reduced REM sleep duration: two randomized controlled trials.

The findings show that exogenous melatonin, when administered at the appropriate time, seems to normalize circadian variation in human physiology and may have a strong impact on general health, especially in the elderly and in shift workers.

Melatonin treatment for age-related insomnia.

Older people typically exhibit poor sleep efficiency and reduced nocturnal plasma melatonin levels. The daytime administration of oral melatonin to younger people, in doses that raise their plasma…

Improvement of sleep quality in elderly people by controlled-release melatonin

Sleep-promoting and hypothermic effects of daytime melatonin administration in humans.

It is suggested that melatonin may be an effective method of promoting sleep for individuals attempting to sleep during their subjective day, such as shiftworkers and individuals rapidly traveling across multiple time zones.
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