Effects of exercise training on muscle GLUT-4 protein content and translocation in obese Zucker rats.

@article{Brozinick1993EffectsOE,
  title={Effects of exercise training on muscle GLUT-4 protein content and translocation in obese Zucker rats.},
  author={J. Brozinick and G. Etgen and B. Yaspelkis and H. Y. Kang and J. Ivy},
  journal={The American journal of physiology},
  year={1993},
  volume={265 3 Pt 1},
  pages={
          E419-27
        }
}
The rates of muscle glucose uptake of trained (TR) and untrained (UT) obese Zucker rats were assessed by hindlimb perfusion under basal conditions (no insulin) in the presence of a maximally stimulating concentration of insulin (10 mU/ml) and after muscle contraction elicited by electrical stimulation of the sciatic nerve. Perfusate contained 28 mM glucose and 7.5 microCi/mmol of 2-deoxy-D-[3H]glucose. Muscle GLUT-4 concentration was determined by Western blot analysis and expressed as a… Expand
Exercise training increases sarcolemmal GLUT-4 protein and mRNA content in diabetic heart.
TLDR
The increase in myocardial sarcolemmal GLUT-4 may be beneficial to the diabetic heart by enhancing myocardian glucose oxidation and cardiac performance. Expand
Troglitazone improves insulin-stimulated glucose utilization associated with an increased muscle glycogen content in obese Zucker rats.
TLDR
Results indicate that troglitazone may improve insulin sensitivity associated with increased muscle glycogen content and has the tendency to increase the activity state of PDH complex in obese and lean rats at the fasting state. Expand
Exercise training improves muscle insulin resistance but not insulin receptor signaling in obese Zucker rats.
TLDR
Results are consistent with the hypothesis that, in obese Zucker rats, adaptations occur during training that lead to improved insulin-stimulated muscle glucose uptake without affecting insulin receptor signaling through the PI3-kinase pathway. Expand
Interactions of exercise training and lipoic acid on skeletal muscle glucose transport in obese Zucker rats.
TLDR
Results indicate that ET and R-ALA interact in an additive fashion to improve insulin action in insulin-resistant skeletal muscle of the obese Zucker rat. Expand
Mechanisms underlying impaired GLUT-4 translocation in glycogen-supercompensated muscles of exercised rats.
TLDR
Results show that both the insulin- and contraction-stimulated pathways for muscle glucose transport activation are impaired in glycogen-supercompensated muscles and provide insight regarding possible mechanisms. Expand
Resistance training increases glucose uptake and transport in rat skeletal muscle.
TLDR
The findings suggest that both resistance or aerobic training exercise can improve insulin-stimulated skeletal muscle glucose uptake and transport, but the training adaptations are restricted to the muscles recruited for the exercise performance. Expand
Training in swimming reduces blood pressure and increases muscle glucose transport activity as well as GLUT4 contents in stroke-prone spontaneously hypertensive rats.
TLDR
Results indicated swimming training exercise improved not only hypertension but also muscle insulin sensitivity and GLUT4 protein expression in SHRSP. Expand
Interactions of exercise training and alpha-lipoic acid on insulin signaling in skeletal muscle of obese Zucker rats.
TLDR
Improvements of insulin action in insulin-resistant skeletal muscle after R-ALA or ET, alone and in combination, were associated with increases in IRS-1 protein expression and IRS- 1 associated with p85. Expand
Interactive Effect of Exercise Training and Growth Hormone Administration on Glucose Tolerance and Muscle GLUT4 Protein Expression in Rats
TLDR
This is the first study that demonstrates that regular exercise training prevents GH-induced insulin-resistance side effect in rats and elevates the curves of the oral glucose tolerance test and insulin response. Expand
Effect of Prolonged Intermittent Hypoxia and Exercise Training on Glucose Tolerance and Muscle GLUT4 Protein Expression in Rats
TLDR
Chronic intermittent hypoxia improved glucose tolerance in the absence of increased GLUT4 protein expression and facilitated the exercise training effect on muscleGLUT4 expression and glycogen storage, which open the possibility of utilizing intermittent Hypoxia, with or without exercise training, for the prevention and clinical treatment of type 2 diabetes or insulin resistance. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 27 REFERENCES
Muscle glucose transport, GLUT-4 content, and degree of exercise training in obese Zucker rats.
TLDR
The effects of high (HI)- and low (LI)-intensity exercise training were examined on insulin-stimulated 3-O-methyl-D-glucose (3-MG) transport and concentration of insulin-regulatable glucose transporter protein (GLUT-4) in the red and white quadriceps of the obese Zucker rat. Expand
Contraction-activated glucose uptake is normal in insulin-resistant muscle of the obese Zucker rat.
TLDR
The results suggest that maximal skeletal muscle glucose uptake of obese Zucker rats is resistant to stimulation by insulin but not to contractile activity and the relationship between contraction-stimulated glucose uptake and GLUT-4 content appears to be fiber-type specific. Expand
Skeletal muscle glucose transport in obese Zucker rats after exercise training.
TLDR
The results suggest that the improvement in the muscle insulin resistance of the obese Zucker rat after moderate endurance training was associated with an improved in the glucose transport process but that it was fiber-type specific. Expand
Effect of endurance training on glucose transport capacity and glucose transporter expression in rat skeletal muscle.
TLDR
The effect of 10 wk endurance swim training on 3-O-methylglucose (3-MG) uptake in skeletal muscle was studied in the perfused rat hindquarter and indicates that the increases in maximum velocity for 3-MG transport in trained muscle is due to an increased number of glucose transporters. Expand
Insulin resistance in soleus muscle from obese Zucker rats. Involvement of several defective sites.
TLDR
Several abnormalities are responsible for insulin resistance of muscles from obese Zucker rats among which the authors have observed decreased insulin binding, decreased glucose transport and increased utilization of endogenous fatty acid which could inhibit glucose utilization. Expand
Glucose Transporter Number, Function, and Subcellular Distribution in Rat Skeletal Muscle After Exercise Training
TLDR
The specific increase in the GLUT4, but not theGLUT1 glucose-transporter isoform, in response to training demonstrates that a common, chronic physiological stimulus can regulate the expression of the two glucose- Transporter isoforms present in skeletal-muscle tissue differentially. Expand
Insulin resistance in obese Zucker rat (fa/fa) skeletal muscle is associated with a failure of glucose transporter translocation.
TLDR
It is concluded that the insulin resistance of the obese rats involves the failure of translocation of transporters, while the action of insulin to increase the average carrier turnover number is normal. Expand
Muscle morphological and biochemical adaptations to training in obese Zucker rats.
TLDR
Results suggest that the Muscle of the obese Zucker rat manifests a greater oxidative capacity than the muscle of its lean littermates, and VO2max and R values during submaximal exercise of the same relative intensity in response to training. Expand
Exercise and diet reduce muscle insulin resistance in obese Zucker rat.
TLDR
It is concluded that exercise training and the high-carbohydrate diet functioned synergistically to reduce the muscle insulin resistance in the obese rat. Expand
Dissociation of effects of insulin and contraction on glucose transport in rat epitrochlearis muscle.
TLDR
It is concluded that insulin and contraction activate glucose transport and metabolism via independent mechanisms. Expand
...
1
2
3
...