Effects of exercise training on insulin-like growth factor-I expression in the skeletal muscle of non-cachectic patients with chronic heart failure.

@article{Hambrecht2005EffectsOE,
  title={Effects of exercise training on insulin-like growth factor-I expression in the skeletal muscle of non-cachectic patients with chronic heart failure.},
  author={Rainer Hambrecht and Paul Christian Schulze and Stephan Gielen and Axel Linke and Sven Moebius-Winkler and Sandra Erbs and J{\"u}rgen Kratzsch Kratzsch and Andreas Schubert and Volker Adams and Gerhard A. Schuler},
  journal={European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology},
  year={2005},
  volume={12 4},
  pages={401-6}
}
BACKGROUND Chronic heart failure (CHF) is associated with progressive muscle atrophy and reduced local expression of insulin-like growth factor I (IGF-I). DESIGN The present study was designed to test the hypothesis that the local deficiency of IGF-I in the skeletal muscle of patients with CHF would respond to a 6-months aerobic training intervention. Therefore, 18 patients [mean age 52.4 (SD 4.8) years, left ventricular ejection function (LVEF) 27 (SD 6)%] were prospectively randomized to… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 48 extracted citations

Heart failure and cachexia: insights offered from molecular biology.

Frontiers in bioscience : a journal and virtual library • 2008
View 14 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…