Effects of exercise training on cardiac function, gene expression, and apoptosis in rats.

@article{Jin2000EffectsOE,
  title={Effects of exercise training on cardiac function, gene expression, and apoptosis in rats.},
  author={H. Jin and R H Yang and W Li and H. Lu and Anne M. Ryan and Annie K. Ogasawara and J Van Peborgh and Nicholas F. Paoni},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2000},
  volume={279 6},
  pages={
          H2994-3002
        }
}
  • H. Jin, R. Yang, +5 authors N. Paoni
  • Published 1 December 2000
  • Biology, Medicine
  • American journal of physiology. Heart and circulatory physiology
This study determined the effects of exercise training on cardiac function, gene expression, and apoptosis. Rats exposed to a regimen of treadmill exercise for 13 wk had a significant increase in cardiac index and stroke volume index and a concomitant decrease in systemic vascular resistance compared with both age-matched and body weight-matched sedentary controls in the conscious state at rest. In exercise-trained animals, there was no change in the expression of several marker genes known to… 
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152 Citations
Highly Influential Citations
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Background Citations
55
Methods Citations
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Results Citations
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152 Citations

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Citation Type

Effects of exercise training on pathological cardiac hypertrophy related gene expression and apoptosis
TLDR
It is suggested that exercise training prevents pathological hypertrophy in the left ventricle by modulation of myocardial genes and that it interferes with a signal transduction pathway of apoptosis secondary to the pathological cardiachypertrophy.
Regional differences in effects of exercise training on contractile and biochemical properties of rat cardiac myocytes.
TLDR
Effects of exercise training on myocyte contractile and biochemical properties are greater in myocytes from the Endo region of the myocardium than those from the Epi region, and results provide evidence that the increase in aMLC1 expression may be responsible for some of the training-induced increase in myocyte Ca2+ sensitivity of tension.
Microarray expression analysis of effects of exercise training: increase in atrial MLC-1 in rat ventricles.
TLDR
Increased expression of atrial myosin light chain 1 (aMLC-1) in response to training may be responsible, at least in part, for previously observed training-induced enhancement of contractile function.
Prior exercise training improves the outcome of acute myocardial infarction in the rat. Heart structure, function, and gene expression.
Exercise training alters length dependence of contractile properties in rat myocardium.
TLDR
It is concluded that exercise training increases the length dependence of maximal and submaximal tension in cardiac myocytes, and this change may underlie, at least in part, training-induced enhancement of myocardial function.
Moderate intensity, but not high intensity, treadmill exercise training alters power output properties in myocardium from aged rats.
  • Eunhee Chung, G. Diffee
  • Biology, Education
    The journals of gerontology. Series A, Biological sciences and medical sciences
  • 2012
TLDR
The results suggest that MI exercise training is beneficial as a significant increase was seen in the ability of the myocardium to do work, but this effect was not seen with HI training.
Mechanism of exercise training-induced myocardial adaptation: alteration of gene expression level
TLDR
Findings suggest that a regulating mechanism of cardiac adaptation-related gene differs between these two types of cardiac hypertrophy, which can lead to the prevention and improvement of lifestyle-related diseases, and to reduction of risk factors in cardiovascular diseases.
Exercise training attenuates age‐induced elevation in Bax/Bcl‐2 ratio, apoptosis, and remodeling in the rat heart
  • H. Kwak, Wook Song, J. Lawler
  • Biology, Medicine
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2006
TLDR
It is found that exercise training provided significant protection against loss of cardiac myocytes, reduction in number of myonuclei, reactive hypertrophy of remaining myocyte, and increased connective tissue in left ventricle of the aging rat heart.
Effects of high-altitude exercise training on contractile function of rat skinned cardiomyocyte.
Effects of adaptive exercise on apoptosis in cells of rat renal tubuli
TLDR
Findings suggested that the acute exercise-induced apoptosis in renal tubules could involve action of AT1 and AT2 receptors as well as oxidative stress, while the regular training was shown to prevent apoptosisIn renal tubular cells via modulated expression of AT 1 and AT1 receptors.
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