Effects of exercise on mitochondrial DNA content in skeletal muscle of patients with COPD.

@article{PuenteMaestu2011EffectsOE,
  title={Effects of exercise on mitochondrial DNA content in skeletal muscle of patients with COPD.},
  author={Lu{\'i}s Puente-Maestu and Alberto L{\'a}zaro and Alberto Tejedor and S. Salva Cama{\~n}o and Marta Fuentes and Miguel Angel Cuervo and Beatriz de Olaiz Navarro and A Agusti},
  journal={Thorax},
  year={2011},
  volume={66 2},
  pages={121-7}
}
BACKGROUND Exhausting exercise reduces the mitochondrial DNA (mtDNA) content in the skeletal muscle of healthy subjects due to oxidative damage. Since patients with chronic obstructive pulmonary disease (COPD) suffer enhanced oxidative stress during exercise, it was hypothesised that the mtDNA content will be further reduced. OBJECTIVE To investigate the effects of exercise above and below the lactate threshold (LT) on the mtDNA content of skeletal muscle of patients with COPD. METHODS… CONTINUE READING
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Decreased exercise-induced expression of NF-kB regulated genes in muscle of COPD patients

  • EM Mercken, GJ Hageman, RC Langen
  • Chest Published Online First: 2010 Aug
  • 2010

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