Effects of etifoxine on ligand binding to GABAA receptors in rodents

@article{Verleye2002EffectsOE,
  title={Effects of etifoxine on ligand binding to GABAA receptors in rodents},
  author={Marc Verleye and Yannick Pansart and Jean-marie Gillardin},
  journal={Neuroscience Research},
  year={2002},
  volume={44},
  pages={167-172}
}
The GABA(A) receptor/chloride ionophore is allosterically modulated by several classes of anxiolytic and anticonvulsant agents, including benzodiazepines, barbiturates and neurosteroids. Etifoxine, an anxiolytic and anticonvulsant compound competitively inhibited the binding of [(35)S]t-butylbicyclophosphoro-thionate (TBPS), a specific ligand of the GABA(A) receptor chloride channel site. To investigate the etifoxine modulatory effects on the different binding sites of the GABA(A) receptor… Expand
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