Effects of etidronate and lovastatin on the regression of atherosclerosis in cholesterol-fed rabbits.

@article{Zhu1994EffectsOE,
  title={Effects of etidronate and lovastatin on the regression of atherosclerosis in cholesterol-fed rabbits.},
  author={Bo-qing Zhu and Y P Sun and Richard E. Sievers and William M. Isenberg and Thomas John Moorehead and William W. Parmley},
  journal={Cardiology},
  year={1994},
  volume={85 6},
  pages={
          370-7
        }
}
Eighty New Zealand rabbits in eight groups (10 each) were fed a 0.5% cholesterol diet for 12 weeks. One group served as a control and was sacrificed at the end of 12 weeks. Seven other groups were shifted to a normal diet and received a drug(s) or placebo for the second 12 weeks. The high dose of etidronate (3 mg/kg/day) with lovastatin (6 mg/kg/day) significantly reduced the percent of aortic atherosclerotic lesions [56 +/- 21 vs. 77 +/- 17% (mean +/- SD), p < 0.05] in the regression study… 
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