Effects of ethanol on tonic GABA currents in cerebellar granule cells and mammalian cells recombinantly expressing GABA(A) receptors.

@article{Yamashita2006EffectsOE,
  title={Effects of ethanol on tonic GABA currents in cerebellar granule cells and mammalian cells recombinantly expressing GABA(A) receptors.},
  author={Megumi Yamashita and William Marszalec and Jay Zeus Yeh and Toshio Narahashi},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2006},
  volume={319 1},
  pages={431-8}
}
The effects of ethanol on the GABA(A) receptors, which are regarded as one of the most important target sites of ethanol, are very controversial, ranging from potentiation to no effect. The delta subunit-containing GABA(A) receptors expressed in Xenopus oocytes were recently reported to be potently augmented by ethanol. We performed patch-clamp experiments using the cerebellar granule cells and mammalian cells expressing recombinant GABA(A) receptors. In granule cells, the sensitivity to GABA… CONTINUE READING

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