Effects of ethanol on glycoprotein synthesis and secretion during inflammation-induced stimulation of hepatic glycoprotein secretion.

@article{Tuma1982EffectsOE,
  title={Effects of ethanol on glycoprotein synthesis and secretion during inflammation-induced stimulation of hepatic glycoprotein secretion.},
  author={Dean J. Tuma and Michael Floyd Sorrell},
  journal={Toxicology and applied pharmacology},
  year={1982},
  volume={63 2},
  pages={
          303-11
        }
}
  • D. Tuma, M. Sorrell
  • Published 1982
  • Biology, Medicine
  • Toxicology and applied pharmacology
Abstract The effects of ethanol on glycoprotein metabolism in liver slices obtained from rats whose synthesis and secretion of glycoproteins had been stimulated by turpentine-induced inflammation were investigated and compared to colchicine, a potent inhibitor of secretion. Inflammation resulted in a large stimulation in liver slices of [ 14 C]glucosamine and [ 14 C]leucine incorporation into medium proteins and a lesser stimulation into hepatocellular proteins. Both ethanol (10 m m ) and… Expand
5 Citations
Effect of ethanol on hepatic secretory proteins.
  • D. Tuma, M. Sorrell
  • Chemistry, Medicine
  • Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism
  • 1984
TLDR
It appears that the final steps of secretion (post-Golgi events) may be the primary site of impairment in this secretory defect, and could contribute to altered levels of plasma proteins and hepatomegaly as well as to the liver injury observed in the alcoholic. Expand
Role of acetaldehyde in the ethanol‐induced impairment of hepatic glycoprotein secretion in the rat In vivo
TLDR
Results indicate that the ethanol‐induced impairment of hepatic glycoprotein secretion is mediated by acetaldehyde in both normal and inflammation‐stimulated animals. Expand
Chronic Ethanol Administration Alters Hepatic Surface Membranes as Evidenced by Decreased Concanavalin A Binding
TLDR
Results indicate that chronic ethanol administration induces changes in the oligosaccharide chains of plasma membrane glycoproteins in the liver, which may play a role in the pathogenesis of alcoholic liver disease. Expand
Ethanol consumption alters trafficking of lysosomal enzymes and affects the processing of procathepsin L in rat liver.
TLDR
It is suggested that chronic ethanol consumption caused a deficiency in intralysosomal enzyme content by altering the trafficking and processing of these hydrolases into lysosomes. Expand
Cytoskeletal Pathology Induced by Ethanol a

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Abstract The effects of ethanol on the metabolism of microsomal glycoproteins and the secretion of export glycoproteins by rat liver slices were investigated and compared to the effects ofExpand
Effect of ethanol on the synthesis and secretion of hepatic secretory glycoproteins and albumin
TLDR
It is shown that ethanol impairs both the synthesis and secretion of secretory glycoproteins and albumin and the effects of ethanol on hepatic protein secretion independent of its effect on synthesis were further determined by prelabeling proteins with either [14C]leucine or [ 14C]fucose. Expand
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TLDR
The results indicate that ethanol via its metabolite, acetaldehyde, impairs the secretion of glycoproteins by the liver and suggest that this impairment follows the attachment of the terminal monosaccharides in the Golgi membrane. Expand
Selective impairment of glycoprotein metabolism by ethanol and acetaldehyde in rat liver slices.
Abstract The mechanism responsible for the ethanol-induced alterations in glycoprotein metabolism was investigated. Inhibitors of peptide synthesis were utilized in a liver slice system to equalizeExpand
Role of acetaldehyde in the ethanol-induced impairment of glycoprotein metabolism in rat liver slices.
TLDR
The data suggest that the ethanol-induced impairment of glycoprotein synthesis and secretion is a consequence of ethanol metabolism and further suggest that this inhibition is attributable to acetaldehyde formation rather than to the altered redox state resulting from ethanol oxidation. Expand
The in vivo effect of colchicine on the addition of galactose and sialic acid to rat hepatic serum glycoproteins.
TLDR
Data indicate that colchicine inhibits secretion of serum proteins by rat liver after the addition of galactose and sialic acid to the secretory proteins has taken place. Expand
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TLDR
It is suggested that the increase in specific radioactivities of medium proteins following incubation of liver slices from experimental rats with labelled leucine and glucosamine is a characteristic of the response of liver to inflammation, and reflects changes in the capacity of liver for the synthesis of alpha-1-acid glycoprotein and other acute phase serum proteins. Expand
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TLDR
The data indicate that an acute dose of ethanol reduced the in vitro protein-synthetic activity of hepatic membrane-bound polyribosomes, while free poly Tribosomes were relatively unaffected. Expand
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TLDR
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TLDR
It was concluded that ethanol reduced hepatocyte protein synthesis without affecting protein degradation, and Hepatocytes appear more sensitive to this effect of ethanol than intact liver preparations, when the present observations are compared with previous results. Expand
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