Effects of ethanol and enzyme-inducing agents on the monooxygenation of testosterone and xenobiotics in rat liver microsomes.

@article{Tredger1984EffectsOE,
  title={Effects of ethanol and enzyme-inducing agents on the monooxygenation of testosterone and xenobiotics in rat liver microsomes.},
  author={John Michael Tredger and H. Gregory Smith and Roger Williams},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1984},
  volume={229 1},
  pages={292-8}
}
The simultaneous production of multiple testosterone oxidation products in hepatic microsomal incubations was monitored after injection of a post-trichloroacetic acid supernatant directly onto a reverse-phase high-performance liquid chromatography column. Twelve testosterone-derived metabolite peaks were detected on the chromatogram and the relative… CONTINUE READING