Effects of ethanol and acetaldehyde in zebrafish brain structures: an in vitro approach on glutamate uptake and on toxicity-related parameters.

@article{Zenki2014EffectsOE,
  title={Effects of ethanol and acetaldehyde in zebrafish brain structures: an in vitro approach on glutamate uptake and on toxicity-related parameters.},
  author={Kamila Cagliari Zenki and Ben Hur Marins Mussulini and Eduardo Pacheco Rico and Diogo L{\"o}sch de Oliveira and Denis B Rosemberg},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2014},
  volume={28 5},
  pages={822-8}
}
Ethanol (EtOH) and its metabolite, acetaldehyde (ALD), induce deleterious effects on central nervous system (CNS). Here we investigate the in vitro toxicity of EtOH and ALD (concentrations of 0.25%, 0.5%, and 1%) in zebrafish brain structures [telencephalon (TE), opticum tectum (OT), and cerebellum (CE)] by measuring the functionality of glutamate transporters, MTT reduction, and extracellular LDH activity. Both molecules decreased the activity of the Na(+)-dependent glutamate transporters in… CONTINUE READING