Effects of etanercept, a tumour necrosis factor-alpha antagonist, in an experimental model of periodontitis in rats.

@article{Paola2007EffectsOE,
  title={Effects of etanercept, a tumour necrosis factor-alpha antagonist, in an experimental model of periodontitis in rats.},
  author={Rosanna di Paola and Emanuela Mazzon and Carmelo Mui{\`a} and Concetta Crisafulli and Dino Terrana and Simona Greco and Domenico Britti and Domenico Santori and Giacomo Oteri and Giancarlo Cordasco and Salvatore Cuzzocrea},
  journal={British journal of pharmacology},
  year={2007},
  volume={150 3},
  pages={286-97}
}
BACKGROUND AND PURPOSE Etanercept is a tumour necrosis factor antagonist with anti-inflammatory effects. The aim of our study was to evaluate, for the first time, the therapeutic efficacy of in vivo inhibition of TNF-alpha in an experimental model of periodontitis. EXPERIMENTAL APPROACH Periodontitis was induced in adult male Sprague-Dawley rats by placing a nylon thread ligature around the lower 1st molars. Etanercept was administered at a dose of 5 mg kg-1, s.c., after placement of the… CONTINUE READING
28 Citations
31 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 28 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 31 references

The pathobiology of periodontal diseases may affect systemic diseases: Inversion of a paradigm

  • RC Page
  • Ann Periodontol
  • 1998
Highly Influential
2 Excerpts

Effect of aminoguanidine in ligature-induced periodontitis in rats

  • R Di Paola, S Marzocco, E Mazzon, F Dattola, F Rotondo, D Britti
  • J Dental Res
  • 2004
4 Excerpts

Similar Papers

Loading similar papers…