Effects of estrogenic compounds on human spermatozoa: evidence for interaction with a nongenomic receptor for estrogen on human sperm membrane

  title={Effects of estrogenic compounds on human spermatozoa: evidence for interaction with a nongenomic receptor for estrogen on human sperm membrane},
  author={Michaela Luconi and Lorella Bonaccorsi and Gianni Forti and Elisabetta Baldi},
  journal={Molecular and Cellular Endocrinology},
17beta-Estradiol and environmental estrogens significantly affect mammalian sperm function.
This study provides the first evidence that E(2) and environmental estrogens can significantly stimulate mammalian sperm capacitation, acrosome reactions and fertilizing ability, with the environmental estrogen being much more potent than E( 2).
Membrane Estrogen Receptors in Human Spermatozoa: An Example of a Non-Classic Steroid Receptor Located in the Membrane
The rapid effects of estrogens arising between seconds to few minutes from stimulation, have been described in different cellular models and such rapid nongenomic effects are initiated at the plasma membrane, but the nature and characteristics of the receptor(s) involved is still a matter of debate.
Nongenomic activation of spermatozoa by steroid hormones: Facts and fictions
Evaluation of the effect of 17alphaOH-progesterone and 17beta-oestradiol on human sperm ability to fuse with oocytes: comparison and possible interference with the effect of progesterone.
A physiological role for 17OH-P in the process of fertilization, but not arole for 17beta-E2 as a possible physiological modulator of P action on spermatozoa is supported.
Influence of estrogen and the endocrine disruptor on the calcitonin functions in teleosts
Using the scale in vitro assay system, it is found that osteoclastic activity accelerated by the estrogen was suppressed by CT, implying that CT protects the scales from excess degradation of calcium at the time of teleost vitellogenesis.
Bisphenol-A Affects Male Fertility via Fertility-related Proteins in Spermatozoa
BPA-induced changes in fertility-related protein levels in spermatozoa may be provided a potential cue of BPA-mediated disease conditions and suggest that high concentrations of B PA alter sperm function, fertilization, and embryonic development via regulation and/or phosphorylation of fertility- related proteins in spermutozoa.


Identification and characterization of a novel functional estrogen receptor on human sperm membrane that interferes with progesterone effects.
The results demonstrate that 17betaE2 induces a rapid and sustained increase of intracellular calcium concentrations ([Ca2+]i), and this effect is totally dependent on the presence of extracellular calcium, because it is completely abolished in a calcium-depleted medium.
Effects of Estrogens and Xenoestrogens on Androgen Production by Atlantic Croaker Testes In Vitro: Evidence for a Nongenomic Action Mediated by an Estrogen Membrane Receptor1
The results demonstrate that estrogens and also probably xenoestrogens can act on the cell surface via a nongenomic mechanism to alter testicular androgen production in this vertebrate species.
Intracellular calcium accumulation and responsiveness to progesterone in capacitating human spermatozoa.
The progressive, parallel increase of [Ca2+]i and response to progesterone observed during in vitro capacitation of human spermatozoa might be physiologically relevant in vivo during capacitating of sperm in the female genital tract.
The environmental estrogen bisphenol A stimulates prolactin release in vitro and in vivo.
BPA mimics estradiol in inducing hyperprolactinemia in genetically predisposed rats and the in vivo action is mediated, at least in part, by increasing PRL regulating factor activity in the posterior pituitary.
Nongenomic actions of steroid hormones in reproductive tissues.
Cross-Talk between the Nongenomic and Genomic Responses of Cells to Steroids VII shows that the GABAA-like receptor/Cl− channel and the PTK system are important sources of uncertainty in the mechanism behind the effects of estrogens.
Rapid membrane effects of steroids in neuroblastoma cells: effects of estrogen on mitogen activated protein kinase signalling cascade and c-fos immediate early gene transcription.
Rapid effects of steroid hormones have been observed in neuronal cells for many years. We show here, that in the human neuroblastoma cell line SK-N-SH, the membrane impermeable conjugated
Specific, nongenomic actions of steroid hormones.
Mechanisms of action are being studied with regard to signal perception and transduction, and researchers have developed a patchy sketch of a membrane receptor-second messenger cascade similar to those involved in catecholamine and peptide hormone action.
Two functional assays of sperm responsiveness to progesterone and their predictive values in in-vitro fertilization.
Assessment of human sperm responsiveness to progesterone may be clinically useful in predicting fertilizing ability in vitro, according to a small cohort of subjects.
Phosphatidylinositol 4,5-bisphosphate hydrolysis in human sperm stimulated with follicular fluid or progesterone is dependent upon Ca2+ influx.
It is reported here that both a Sephadex G-75 column fraction, derived from follicular fluid, and progesterone stimulate rapid hydrolysis of PtdIns(4,5)P2 and PTDIns4P in human sperm and that progester one stimulates a rapid influx of Ca2+ inhuman sperm.
Molecular basis of agonism and antagonism in the oestrogen receptor
The crystal structures of the LBD of ER in complex with the endogenous oestrogen, 17β-oestradiol, and the selective antagonist raloxifene provide a molecular basis for the distinctive pharmacophore of the ER and its catholic binding properties.