Effects of estrogenic compounds on human spermatozoa: evidence for interaction with a nongenomic receptor for estrogen on human sperm membrane

@article{Luconi2001EffectsOE,
  title={Effects of estrogenic compounds on human spermatozoa: evidence for interaction with a nongenomic receptor for estrogen on human sperm membrane},
  author={Michaela Luconi and Lorella Bonaccorsi and Gianni Forti and Elisabetta Baldi},
  journal={Molecular and Cellular Endocrinology},
  year={2001},
  volume={178},
  pages={39-45}
}
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69 Citations

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The rapid effects of estrogens arising between seconds to few minutes from stimulation, have been described in different cellular models and such rapid nongenomic effects are initiated at the plasma membrane, but the nature and characteristics of the receptor(s) involved is still a matter of debate.
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A physiological role for 17OH-P in the process of fertilization, but not arole for 17beta-E2 as a possible physiological modulator of P action on spermatozoa is supported.
Estrogen receptor independent rapid non-genomic effects of environmental estrogens on [Ca2+]i in human breast cancer cells
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Using the scale in vitro assay system, it is found that osteoclastic activity accelerated by the estrogen was suppressed by CT, implying that CT protects the scales from excess degradation of calcium at the time of teleost vitellogenesis.
Bisphenol-A Affects Male Fertility via Fertility-related Proteins in Spermatozoa
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BPA-induced changes in fertility-related protein levels in spermatozoa may be provided a potential cue of BPA-mediated disease conditions and suggest that high concentrations of B PA alter sperm function, fertilization, and embryonic development via regulation and/or phosphorylation of fertility- related proteins in spermutozoa.
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The results demonstrate that 17betaE2 induces a rapid and sustained increase of intracellular calcium concentrations ([Ca2+]i), and this effect is totally dependent on the presence of extracellular calcium, because it is completely abolished in a calcium-depleted medium.
Effects of Estrogens and Xenoestrogens on Androgen Production by Atlantic Croaker Testes In Vitro: Evidence for a Nongenomic Action Mediated by an Estrogen Membrane Receptor1
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The results demonstrate that estrogens and also probably xenoestrogens can act on the cell surface via a nongenomic mechanism to alter testicular androgen production in this vertebrate species.
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The progressive, parallel increase of [Ca2+]i and response to progesterone observed during in vitro capacitation of human spermatozoa might be physiologically relevant in vivo during capacitating of sperm in the female genital tract.
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TLDR
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TLDR
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TLDR
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