Effects of estrogen replacement on insulin-like growth factor I concentrations in serum and bone tissue and on interleukin 1 secretion from spleen macrophages in oophorectomized rats

@article{Sato1993EffectsOE,
  title={Effects of estrogen replacement on insulin-like growth factor I concentrations in serum and bone tissue and on interleukin 1 secretion from spleen macrophages in oophorectomized rats},
  author={Fumiyasu Sato and Yasuyoshi Ouchi and Akihiro Masuyama and Tetsuro Nakamura and Takayuki Hosoi and Yasushi Okamoto and Norio Sasaki and M Shiraki and Hajime Orimo},
  journal={Calcified Tissue International},
  year={1993},
  volume={53},
  pages={111-116}
}
Oophorectomy (OOX) has been known to increase bone turnover, but its precise mechanism is not fully understood. In order to further investigate the mechanism, we determined insulinlike growth factor I (IGF-I) concentrations in serum and bone tissue and interleukin 1 (IL-1) release from spleen macrophages in oophorectomized rats because it has been demonstrated that IGF-I stimulates bone formation and IL-1 stimulates bone resorption. Female 8-week-old Wistar rats were divided into four groups… CONTINUE READING

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