Effects of estrogen replacement on infarct size, cardiac remodeling, and the endothelin system after myocardial infarction in ovariectomized rats.

@article{Smith2000EffectsOE,
  title={Effects of estrogen replacement on infarct size, cardiac remodeling, and the endothelin system after myocardial infarction in ovariectomized rats.},
  author={Peter Jeffry Smith and Olga I. Ornatsky and Duncan J Stewart and Pierre Picard and Feroza Dawood and Wen H. Wen and Peter Liu and David J. Webb and Juan Carlos Monge},
  journal={Circulation},
  year={2000},
  volume={102 24},
  pages={2983-9}
}
BACKGROUND Estrogen may increase the long-term survival of women who have suffered from a myocardial infarction (MI). We examined the acute and chronic influence of estrogen on MI in the rat left coronary artery ligation model. METHODS AND RESULTS Female Sprague-Dawley rats (10 to 12 weeks, n=93), divided into 3 groups (rats with intact ovaries, ovariectomized rats administered 17beta-estradiol [17beta-E(2)] replacement, and ovariectomized rats administered placebo 2 weeks before MI), were… CONTINUE READING

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Are there gender differences in left ventricular remodeling after myocardial infarction in rats?

Revista brasileira de cirurgia cardiovascular : orgao oficial da Sociedade Brasileira de Cirurgia Cardiovascular • 2015
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