Effects of estrogen receptor and estrogen on the chromatin structure in estrogen receptor stable transfectants

@article{Lee2002EffectsOE,
  title={Effects of estrogen receptor and estrogen on the chromatin structure in estrogen receptor stable transfectants},
  author={Young Joo Lee and Won Chung Lim and Ying Hua Jin and Seung Ki Lee},
  journal={Experimental & Molecular Medicine},
  year={2002},
  volume={34},
  pages={95-99}
}
The estrogen receptor (ER), a member of the nuclear hormone receptor superfamily recruits coactivators that modify local chromatin structure. Here we investigated the effect of the estrogen receptor and estrogen on the global chromatin structure and the local chromatin structure of the progesterone receptor gene during the process of transcriptional activation using Rat1+ER cells stably expressing the estrogen receptor. The total chromatin was more accessible to DNasel in Rat1+ER cells than in… CONTINUE READING

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