Effects of estrogen and raloxifene on neuroglia number and morphology in the hippocampus of aged female mice.

@article{Lei2003EffectsOE,
  title={Effects of estrogen and raloxifene on neuroglia number and morphology in the hippocampus of aged female mice.},
  author={D-L Lei and Jeffrey M. Long and John Hengemihle and John O'Neill and Kebreten F. Manaye and Donald K. Ingram and Peter R. Mouton},
  journal={Neuroscience},
  year={2003},
  volume={121 3},
  pages={659-66}
}
Hormone replacement therapy with the gonadal steroid estrogen or synthetic agents such as raloxifene, a selective estrogen receptor modulator, may affect cellular function in brains of postmenopausal women. In vitro studies suggest that 17beta estradiol and raloxifene can alter the microglial and astrocyte expression of immuno-neuronal modulators, such as cytokines, complement factors, chemokines, and other molecules involved in neuroinflammation and neurodegeneration. To directly test whether… CONTINUE READING

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