Effects of estrogen and antiestrogen on DNA polymerase in human breast cancer.

@article{Edwards1980EffectsOE,
  title={Effects of estrogen and antiestrogen on DNA polymerase in human breast cancer.},
  author={Dean P. Edwards and S. Ramachandra Murthy and William L. McGuire},
  journal={Cancer research},
  year={1980},
  volume={40 5},
  pages={1722-6}
}
We have investigated the effects of estrogens and antiestrogens on cellular DNA-dependent DNA polymerase activity in human breast cancer, using as a model the MCF-7 human breast cancer cell line which contains estrogen receptor. 17 beta-Estradiol had little if any effect on cytosol DNA polymerase activity or growth (total DNA per flask) of MCF-7 cells. Incubation of the cells for 4 to 6 days with the antiestrogen nafoxidine, however, resulted in a dose-dependent reduction in cytosol DNA… CONTINUE READING

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