Effects of estradiol on insulin receptor distribution in primary cultures of R3230AC mammary adenocarcinoma of the rat.

Abstract

The influence of 17 beta-estradiol on insulin receptor distribution was studied in primary cultures of R3230AC mammary tumors prepared from intact or ovariectomized Fischer rats. [125I] Insulin binding to plasma membrane (IRS) and to solubilized cells (IRt) was measured, and intracellular insulin binding (IRi) was calculated by the difference between the… (More)

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