Effects of estradiol on glycemic and CNS neuronal activational responses to recurrent insulin-induced hypoglycemia in the ovariectomized female rat.

@article{Nedungadi2006EffectsOE,
  title={Effects of estradiol on glycemic and CNS neuronal activational responses to recurrent insulin-induced hypoglycemia in the ovariectomized female rat.},
  author={Thekkethil Prashant Nedungadi and Wanda L Goleman and Sachin A. Paranjape and Ajay Y. Kale and Karen P Briski},
  journal={Neuroendocrinology},
  year={2006},
  volume={84 4},
  pages={235-42}
}
Recurrent insulin-induced hypoglycemia (RIIH) results in glucose counterregulatory dysfunction in men and male rodents. Intensified hypoglycemia in the latter coincides with diminished neuronal Fos expression in central metabolic regulatory structures, evidence that supports habituation of CNS-mediated compensatory motor outflow during re-exposure to this metabolic stress. In light of the evidence for counterregulatory resistance to precedent hypoglycemia in women, we utilized estradiol-treated… CONTINUE READING

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