Effects of essential oils from herbal plants and citrus fruits on DNA polymerase inhibitory, cancer cell growth inhibitory, antiallergic, and antioxidant activities.

@article{Mitoshi2012EffectsOE,
  title={Effects of essential oils from herbal plants and citrus fruits on DNA polymerase inhibitory, cancer cell growth inhibitory, antiallergic, and antioxidant activities.},
  author={Mai Mitoshi and Isoko Kuriyama and Hiroto Nakayama and Hironari Miyazato and Keiichiro Sugimoto and Yuko Kobayashi and Tomoko Jippo and Kazuki Kanazawa and Hiromi Yoshida and Yoshiyuki Mizushina},
  journal={Journal of agricultural and food chemistry},
  year={2012},
  volume={60 45},
  pages={
          11343-50
        }
}
In this study, the biological activity of 20 essential oils (EOs) from herbal plants and citrus fruits were investigated in terms of mammalian DNA polymerase (pol) inhibitory activity, cancer cell (human colon carcinoma, HCT116) growth inhibitory activity, antiallergic activity, as anti-β-hexosaminidase release activity in rat basophilic leukemia RBL-2H3 cells treated with calcium ionophore A23187, and antioxidant activity by a lipophilic-oxygen radical absorbance capacity method. These EOs… 
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References

SHOWING 1-10 OF 44 REFERENCES
Antiproliferative and apoptotic effects of chamomile extract in various human cancer cells.
TLDR
Ex vivo experiments suggest that deconjugation of glycosides occurs in vivo to produce aglycone, especially in the small intestine, and further investigations of the mechanism of action of chamomile are warranted in evaluating the potential usefulness of this herbal remedy in the management of cancer patients.
Biological effects of essential oils--a review.
Specific Inhibitors of Mammalian DNA Polymerase Species
  • Y. Mizushina
  • Biology, Chemistry
    Bioscience, biotechnology, and biochemistry
  • 2009
TLDR
Dhydroaltenusin and curcumin derivatives were found to be specific inhibitors of pol α and pol λ, respectively, and might be useful not only as “molecular probes” for pol research, but also as biomedical and chemotherapeutic drugs for anti-cancer or anti-inflammation.
Antioxidant and antimicrobial activities of the edible medicinal halophyte Tamarix gallica L. and related polyphenolic constituents.
  • R. Ksouri, H. Falleh, C. Abdelly
  • Medicine, Chemistry
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2009
Antibacterial activity of essential oil components and their potential use in seed disinfection.
TLDR
The data indicate eugenol as potentially useful for bean seed disinfection from X. campestris pv.
Study on the antiinflammatory activity of essential oil from leaves of Cinnamomum osmophloeum.
TLDR
This study is the first to report antiinflammatory activity of extracts obtained from the leaf essential oil of C. osmophloeum, suggesting that essential oil was bioactive in antiinflammation in vitro.
...
...