Effects of erythropoietin-gene electrotransfer in rats with adenine-induced renal failure.

@article{Ataka2003EffectsOE,
  title={Effects of erythropoietin-gene electrotransfer in rats with adenine-induced renal failure.},
  author={Ken Ataka and Hiroki Maruyama and Tomohiro Neichi and Jun-Ichi Miyazaki and Fumitake Gejyo},
  journal={American journal of nephrology},
  year={2003},
  volume={23 5},
  pages={315-23}
}
BACKGROUND We previously demonstrated that erythropoietin (Epo) expression increases in five-sixths nephrectomized rats, after muscle-targeted gene transfer by in vivo electroporation, using plasmid DNA expressing rat Epo (pCAGGS-Epo). Here, we apply this method to a rat model with severe anemia associated with chronic renal failure; these rats have hematocrit levels in the 30-35% range, similar to those in humans with end-stage renal disease. METHODS Wistar rats were treated to produce… CONTINUE READING
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