Effects of ergotamine and dihydroergotamine on 5-hydroxytryptamine-2A receptors in the isolated rat aorta.

@article{Kalkman1996EffectsOE,
  title={Effects of ergotamine and dihydroergotamine on 5-hydroxytryptamine-2A receptors in the isolated rat aorta.},
  author={Hans Otto Kalkman and Ferenc Schneider},
  journal={Pharmacology},
  year={1996},
  volume={53 6},
  pages={
          351-5
        }
}
  • Hans Otto Kalkman, Ferenc Schneider
  • Published 1996
  • Chemistry, Medicine
  • Pharmacology
  • Ergotamine contracted isolated rat aorta rings with an intrinsic activity of 50% of that of 5-hydroxytryptamine. (5-HT, 0.1 mmol/l). Dihydroergotamine did not contract the tissue, but insurmountably blocked contraction in response to ergotamine and 5-HT. The 5-HT2A receptor antagonist, ketanserin (0.1 mumol/l), inhibited ergotamine (pKB 8.0) and 5-HT (pKB 8.1) induced contractions. These results indicate that in the rat aorta ergotamine is a partial 5-HT2A receptor agonist, whilst… CONTINUE READING

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