• Biology, Medicine
  • Published in
    Journal of agricultural and…
    2006
  • DOI:10.1021/jf060626u

Effects of ergot alkaloids on food preference and satiety in rabbits, as assessed with gene-knockout endophytes in perennial ryegrass (Lolium perenne).

@article{Panaccione2006EffectsOE,
  title={Effects of ergot alkaloids on food preference and satiety in rabbits, as assessed with gene-knockout endophytes in perennial ryegrass (Lolium perenne).},
  author={Daniel G Panaccione and Jessica R Cipoletti and Andrea B Sedlock and Kenneth P. Blemings and Christopher L. Schardl and Caroline Machado and George E. Seidel},
  journal={Journal of agricultural and food chemistry},
  year={2006},
  volume={54 13},
  pages={
          4582-7
        }
}
Neotyphodium species are fungal endophytes best known for their protection of grass hosts and production of bioactive metabolites including ergot alkaloids. Perennial ryegrass-Neotyphodium sp. Lp1 symbiota that have altered ergot alkaloid profiles (resulting from knockouts in two different endophyte genes) were fed, along with controls, to rabbits to test the effects of ergot alkaloids on food preference and satiety. Interestingly, rabbits dramatically preferred plants that were endophyte… CONTINUE READING

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