Effects of equine recombinant interleukin-1alpha and interleukin-1beta on proteoglycan metabolism and prostaglandin E2 synthesis in equine articular cartilage explants.

@article{Takafuji2002EffectsOE,
  title={Effects of equine recombinant interleukin-1alpha and interleukin-1beta on proteoglycan metabolism and prostaglandin E2 synthesis in equine articular cartilage explants.},
  author={Vivian A Takafuji and C W Mcilwraith and Rick D Howard},
  journal={American journal of veterinary research},
  year={2002},
  volume={63 4},
  pages={551-8}
}
OBJECTIVES To evaluate the effects of equine recombinant interleukin-1alpha (rEqIL-1alpha) and recombinant interleukin-1beta (rEqIL-1beta) on proteoglycan metabolism and prostaglandin E2 (PGE2) synthesis by equine articular chondrocytes in explant culture. SAMPLE POPULATION Near full-thickness articular cartilage explants (approx 50 mg) harvested from stifle joints of a 3-year-old and a 5-year-old horse. PROCEDURE Expression constructs containing cDNA sequences encoding EqIL-1alpha and EqIL… CONTINUE READING
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