Effects of epidermal growth factor on fibroblast migration through biomimetic hydrogels.

@article{Gobin2003EffectsOE,
  title={Effects of epidermal growth factor on fibroblast migration through biomimetic hydrogels.},
  author={Andrea S. Gobin and Jennifer L West},
  journal={Biotechnology progress},
  year={2003},
  volume={19 6},
  pages={1781-5}
}
We have previously reported on the development and use of synthetic hydrogel extracellular matrix (ECM) analogues that can be used to study the mechanisms of migration. These biomimetic hydrogels consist of bioinert poly(ethylene glycol) diacrylate derivatives with proteolytically degradable peptide sequences included in the backbone of the polymer and adhesion peptide sequences grafted into the network. Cells adhere to the hydrogel via interaction between the grafted adhesion ligands and… CONTINUE READING